DEX-SSBAP30-FA

DEX-SSBAP30-FA is a **folate (FA)-conjugated, disulfide-based cationic dextran polymer** designed for targeted **gene delivery**, particularly to cancer cells overexpressing folate receptors such as SKOV-3 ovarian cancer cells[1][5]. The formulation exploits a high density of primary amine side groups for effective DNA binding and in vivo delivery. The FA-conjugation confers tumor-targeting capability via folate receptor-mediated endocytosis. In preclinical models, DEX-SSBAP30-FA demonstrated efficient gene transfer by intravenous injection, low cytotoxicity, and improved tumor targeting compared to non-FA-conjugated analogs and performance comparable to established polymeric gene delivery vectors like linear polyethylenimine[1][5].

Brand names

Dex-SSBAP30-FADex-SSBAP-30-FADex-SSBAP 30-FA

Other names

Dex-SSBAP30-FADex-SSBAP-30-FADex-SSBAP 30-FA