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dexamethasone + methylprednisolone (Vanderbilt University Medical Center)
- Development stage
- Unknown
- Lead developer
- Vanderbilt University Medical Center
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A perioperative glucocorticoid regimen consisting of a single intraoperative dose of intravenous dexamethasone followed by a six-day oral methylprednisolone taper. Developed by Vanderbilt University Medical Center, this combination is being investigated in the SAFE Trial (Steroid Administration for Articular Fractures of the Elbow) to improve post-operative range of motion in patients with intra-articular elbow fractures requiring surgery. The treatment aims to mitigate the inflammatory response and prevent joint stiffness or heterotopic ossification by suppressing pro-inflammatory cytokines.
- Other names
- perioperative glucocorticoidsSAFE Trial steroid regimen
02
Targets
GR (Glucocorticoid receptor)
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