dexamethasone + hyaluronic acid

Dexamethasone + hyaluronic acid is a combination drug formulation that pairs dexamethasone, a potent synthetic glucocorticoid corticosteroid with anti-inflammatory and immunosuppressive properties, with hyaluronic acid, a naturally occurring glycosaminoglycan used as a biocompatible vehicle for drug delivery. This combination is primarily investigated for local administration—such as intratympanic injection in the middle ear or intra-articular injection in joints—to enhance the therapeutic effect of dexamethasone by prolonging its residence time at the target site and improving tissue penetration. Hyaluronic acid acts both as a passive structural molecule (providing viscosity and sustained release) and may modulate tissue permeability to facilitate steroid uptake. The main clinical indications under investigation include sudden sensorineural hearing loss (SSNHL), Ménière's disease-related hearing loss, osteoarthritis (for joint injections), and potentially severe lung inflammation via inhalable nanoparticles[1][2][3][4][5][7][8].

Other names

dexamethasone and hyaluronic aciddexamethasone/hyaluronic acid