Drug intelligence / Profile preview

dexamethasone + moxifloxacin + ketorolac

Development stage
Unknown
Lead developer
ImprimisRx
Modality
Small Molecules
Administration
Ophthalmic, Intracameral
01

Overview

**Dexamethasone + moxifloxacin + ketorolac** is a preservative-free compounded ophthalmic combination drug used primarily in cataract and other ocular surgeries to reduce postoperative inflammation, prevent bacterial endophthalmitis, and manage pain. It combines **dexamethasone**, a synthetic glucocorticoid corticosteroid that binds glucocorticoid receptors to inhibit pro-inflammatory signals and promote anti-inflammatory pathways; **moxifloxacin**, a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV for broad-spectrum antibacterial activity; and **ketorolac**, a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby alleviating pain and inflammation. Administered as an intracameral injection (typically dexamethasone 1 mg/mL, moxifloxacin 0.5 mg/mL, ketorolac 0.4 mg/mL), it supports dropless cataract surgery protocols by simplifying postoperative care and improving patient adherence.[1][3][7]

Brand names
Dex-Moxi-KetorMoxifl-Dexame-Ketorol-Nacl(Pf)DEXMOXIKETOR PFDex-Moxi-Ketor PF
Other names
dexamethasone - moxifloxacin - ketorolac pfDex-Moxi-Ketordexamethasone sodium phosphate + moxifloxacin hydrochloride monohydrate + ketorolac tromethamine
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)GR (Glucocorticoid receptor)Topo IV (Bacterial Topoisomerase IV)DNA gyrase

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