Drug intelligence / Profile preview

dexamethasone + ofloxacin

Development stage
Unknown
Lead developer
Laboratório EDOL Produtos Farmacêuticos
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Flokort is an ophthalmic solution containing dexamethasone (as dexamethasone sodium phosphate) and ofloxacin. Developed by Laboratório EDOL, it is approved in Portugal for the treatment of inflammatory eye conditions and bacterial eye infections, particularly in pre- and post-operative ocular surgery settings where infection and inflammation coexist. Dexamethasone is a potent corticosteroid that reduces inflammation, redness, and swelling by binding to and activating the glucocorticoid receptor, thereby inhibiting prostaglandin synthesis. Ofloxacin is a broad-spectrum fluoroquinolone antibiotic that exerts bactericidal activity by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing bacterial DNA replication, transcription, and repair.

Brand names
Flokort
Other names
dexamethasone + ofloxacindexamethasone sodium phosphate + ofloxacinfosfato de dexametasona + ofloxacinaofloxacin + dexamethasone
02

Targets

DNA gyraseTopo IV (Bacterial Topoisomerase IV)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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