Drug intelligence / Profile preview

dexamethasone + oseltamivir

Development stage
Unknown
Lead developer
National Natural Science Foundation of China
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous
01

Overview

Dexamethasone + oseltamivir is a combination therapy consisting of dexamethasone, a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties, and oseltamivir, an oral neuraminidase inhibitor antiviral agent. This combination has been investigated for its potential synergistic effects in the management of newly diagnosed primary immune thrombocytopenia (ITP), where dexamethasone suppresses immune-mediated platelet destruction and oseltamivir may enhance platelet response by inhibiting sialidase activity. The regimen has also been studied in severe influenza to assess whether adding dexamethasone to standard antiviral treatment improves clinical outcomes[1][2][4][5].

02

Targets

GR (Glucocorticoid receptor)Neuraminidase

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