Drug intelligence / Profile preview

dexamethasone + prednisone + recombinant human thrombopoietin

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules, Recombinant Proteins and Enzymes
Administration
Oral, Intravenous, Subcutaneous
01

Overview

This is a combination therapy consisting of two corticosteroids (dexamethasone and prednisone) and a recombinant cytokine (recombinant human thrombopoietin, rhTPO). Dexamethasone and prednisone are synthetic glucocorticoids that suppress immune responses, reduce inflammation, and inhibit platelet destruction in immune thrombocytopenia (ITP). Recombinant human thrombopoietin is a cytokine that stimulates megakaryocyte proliferation and differentiation, thereby increasing platelet production. The combination is not standard for any specific disease but may be considered in refractory or severe cases of ITP or other forms of thrombocytopenia where both immunosuppression and enhanced platelet production are desired[2][3][7].

Other names
dexamethasone and prednisone and rhTPOdexamethasone plus prednisone plus rhTPO
02

Targets

GR (Glucocorticoid receptor)TPOR (Thrombopoietin receptor)

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