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Drug intelligence / Profile preview
dexamethasone palmitate
- Development stage
- Unknown
- Lead developer
- Mitsubishi Tanabe Pharma
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Dexamethasone palmitate is a lipophilic prodrug of the synthetic glucocorticoid dexamethasone. It is formulated as a lipid emulsion, a delivery system often referred to as "limo-dexamethasone," which is designed to target inflamed tissues by being selectively taken up by macrophages through phagocytosis. Once inside the cell, the palmitate ester is cleaved to release the active dexamethasone, which then binds to the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects. This targeted delivery mechanism is intended to improve the therapeutic index by concentrating the drug at the site of inflammation, such as in rheumatoid arthritis, while potentially reducing systemic side effects associated with conventional corticosteroid therapy. Doritsu is a brand name for this formulation, originally developed by Green Cross Corporation (now Mitsubishi Tanabe Pharma).
- Brand names
- DoritsuLimethason
- Other names
- dexamethasone 21-palmitatedexamethasone21-palmitatedexamethasone-21-palmitatelimo-dexamethasone
02
Targets
ESRRA (Estrogen-related receptor alpha)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)
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