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dexamethasone palmitate low-density lipoprotein complex
- Development stage
- Preclinical
- Lead developer
- Hokkaido College of Pharmacy
- Modality
- Small Molecules, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**Dexamethasone palmitate low-density lipoprotein complex** is an experimental LDL-based targeted drug-delivery system for atherosclerosis. It incorporates the lipophilic glucocorticoid prodrug dexamethasone palmitate into low-density lipoprotein particles to promote accumulation in atherosclerotic lesions. Following oxidative modification, the complex is taken up by macrophages and foam cells through scavenger-receptor-mediated pathways; released dexamethasone is intended to suppress cholesterol ester accumulation and foam-cell formation. In atherogenic mouse studies, intravenous DP-LDL complex reduced aortic cholesterol ester accumulation more potently than dexamethasone or dexamethasone-palmitate lipid emulsion comparators. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14577972/))
- Other names
- DP-LDL complexdexamethasone palmitate (DP)-low density lipoprotein (LDL) complexdexamethasone palmitate-LDL complex
02
Targets
GR (Glucocorticoid receptor)CD36 (CD36 antigen)
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