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dexanabinol + nab-paclitaxel + gemcitabine
- Development stage
- Phase 1
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
This combination therapy consists of the synthetic cannabinoid derivative dexanabinol (ETS2101) administered alongside the standard-of-care chemotherapy doublet, nab-paclitaxel and gemcitabine. Dexanabinol is a non-psychotropic, non-competitive NMDA receptor antagonist that also inhibits TNF-alpha and NF-kappaB signaling. In the context of oncology, dexanabinol is hypothesized to act as a chemosensitizer, potentially enhancing the efficacy of cytotoxic agents by modulating the tumor microenvironment and reducing inflammatory signaling that contributes to resistance. nab-Paclitaxel is an albumin-bound formulation of paclitaxel that promotes microtubule assembly and prevents disassembly, while gemcitabine is a nucleoside analog that inhibits DNA synthesis. This triplet regimen has been primarily investigated in clinical trials for the treatment of advanced or metastatic pancreatic ductal adenocarcinoma (PDAC).
- Other names
- ETS2101 + nab-paclitaxel + gemcitabineHU-211 + nab-paclitaxel + gemcitabine
02
Targets
CDA (Cytidine deaminase)DNANMDAR (Glutamate receptor ionotropic, NMDA)RNR (Ribonucleotide reductase)TUBB (Tubulin (alpha and beta subunits))TNFA (Tumor necrosis factor alpha (soluble))
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