dexetimide

Dexetimide is a small molecule piperidine anticholinergic drug, primarily used as a muscarinic antagonist for the treatment of neuroleptic-induced parkinsonism and other extrapyramidal symptoms. It acts by blocking muscarinic acetylcholine receptors (mAChRs), thereby inhibiting the action of acetylcholine in both central and peripheral nervous systems. This mechanism helps alleviate symptoms associated with cholinergic dysfunction, such as those seen in Parkinson's disease and drug-induced extrapyramidal disorders. Dexetimide was discovered at Janssen Pharmaceutica in 1968 and marketed under the brand name Tremblex. It is considered potent, long-acting, and has high affinity for all subtypes of muscarinic receptors[1][2][5][6].

Brand names

Tremblex

Other names

DexetimidaDexetimidum