dexketoprofen + thiamine + pyridoxine + cyanocobalamin

Dexketoprofen + thiamine + pyridoxine + cyanocobalamin is a **fixed-dose combination drug** consisting of a nonsteroidal anti-inflammatory drug (NSAID)—**dexketoprofen**—and three B-vitamins: **thiamine** (B1), **pyridoxine** (B6), and **cyanocobalamin** (B12). It is developed for the treatment of **acute pain in musculoskeletal disorders**, particularly grade I–II cervical sprains[1][3][5]. Dexketoprofen acts mainly as a **COX inhibitor**, providing analgesic and anti-inflammatory effects. The B vitamins contribute additional analgesic activity, believed to work through multiple mechanisms, such as **modulation of neurotransmitter synthesis**, **antioxidant and anti-inflammatory pathways**, **activation of adenosine receptors**, **modulation of voltage-gated sodium channels** (thiamine), and **GABAergic/serotonergic activity** (pyridoxine, cyanocobalamin)[5]. This combination has demonstrated **superior efficacy and better safety profile** in reducing pain intensity and adverse events compared to dexketoprofen monotherapy in phase IIIb trials for cervical sprain pain[1][5].

Brand names

Dexketoprofen/Vitamin B

Other names

Dexketoprofen + Vitamin B complexDexketoprofen + Vitamin B1 + B6 + B12