Drug intelligence / Profile preview

Dexketoprofen trometamol (Atatürk University)

Development stage
Unknown
Lead developer
Menarini
Modality
Small Molecules
Administration
Intravenous, Oral, Intramuscular
01

Overview

Dexketoprofen trometamol is a water-soluble salt of the S(+)-enantiomer of ketoprofen, a non-steroidal anti-inflammatory drug (NSAID). It functions as a non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are enzymes responsible for the synthesis of prostaglandins involved in pain and inflammation. Due to its trometamol salt formulation, it exhibits rapid absorption and a quick onset of analgesic action. Ataturk University has conducted Phase 4 research into its use for renal colic, specifically comparing intravenous dexketoprofen trometamol to ultrasound-guided erector spinae plane blocks for acute pain management.

Brand names
EnantyumKeralDexalKetesse
Other names
Dexketoprofen tromethamine(S)-Ketoprofen trometamol
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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