dexketoprofen trometamol + pethidine hydrochloride

Dexketoprofen trometamol + pethidine hydrochloride is a combination analgesic formulation containing two active ingredients with distinct mechanisms of action. Dexketoprofen trometamol is the tromethamine salt of dexketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that acts as a non-selective cyclooxygenase (COX-1 and COX-2) inhibitor, reducing prostaglandin synthesis to provide anti-inflammatory and analgesic effects[10][6]. Pethidine hydrochloride (also known as meperidine) is an opioid analgesic that acts primarily as an agonist at the mu-opioid receptor in the central nervous system, producing potent pain relief and sedation[2][5][1]. The combination aims to provide multimodal pain control by targeting both inflammatory and nociceptive pathways. This approach may offer synergistic or additive analgesia for moderate to severe acute pain, such as postoperative or procedural pain[6][8].