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dexmedetomidine + bupivacaine (Hospital Central Dr. Luis Ortega)
- Development stage
- Unknown
- Lead developer
- Orion Pharma
- Modality
- Small Molecules
- Administration
- Intrathecal
01
Overview
Dexmedetomidine + bupivacaine is a combination of a highly selective alpha-2 adrenergic receptor agonist and a local anesthetic, being studied as a spinal anesthesia regimen. Dexmedetomidine acts as an adjuvant to enhance the sensory and motor block of bupivacaine while prolonging postoperative analgesia. This specific formulation and study were conducted at Hospital Central Dr. Luis Ortega for patients undergoing lower abdominal surgeries. The combination is administered subarachnoideally (intrathecally) to provide effective anesthesia and analgesia without significant hemodynamic compromise.
- Other names
- dexmedetomidine and bupivacainedexmedetomidine plus hyperbaric bupivacainedexmedetomidine + bupivacaine-Hospital Central Dr. Luis Ortega
02
Targets
ADRA2A (α2A)NaV (Voltage-gated sodium channels)
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