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dexmedetomidine + dexamethasone
- Development stage
- Phase 4
- Lead developer
- Gachon University Gil Medical Center
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
The combination of dexmedetomidine and dexamethasone is an investigational therapy being evaluated for the prevention of postoperative nausea and vomiting (PONV). Dexmedetomidine is a highly selective alpha-2 adrenergic receptor agonist that provides sedative, analgesic, and antiemetic effects. Dexamethasone is a potent corticosteroid that exerts antiemetic properties by inhibiting inflammatory mediators and potentially interacting with various neurotransmitter receptors. This specific combination was studied in a randomized clinical trial (NCT02550795) led by Gachon University Gil Medical Center, specifically targeting female patients undergoing breast cancer surgery. The treatment involves a single intravenous dose administered prior to the conclusion of surgery to mitigate the high incidence of PONV associated with general anesthesia and surgical procedures.
- Other names
- dexmedetomidine and dexamethasone
02
Targets
ADRA1A (α1A)ADRA2A (α2A)NeuraminidaseGR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)ADRA2B (α2B)ADRA2C (α2C)
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