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dexmedetomidine + tramadol + flurbiprofen
- Development stage
- Preclinical
- Lead developer
- Orion Pharma
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A multimodal analgesic combination used for patient-controlled intravenous analgesia (PCIA) in postoperative pain management. This combination leverages the complementary mechanisms of action of its components: dexmedetomidine (a highly selective α2-adrenergic receptor agonist with sedative and analgesic properties), tramadol (an opioid with μ-receptor agonist activity and serotonin/norepinephrine reuptake inhibition), and flurbiprofen (a nonsteroidal anti-inflammatory drug). The combination aims to provide effective pain relief while potentially reducing opioid-related side effects and improving patient outcomes.
02
Targets
ADRA2A (α2A)SERT (Sodium-dependent serotonin transporter)PGHS-1 (Prostaglandin G/H Synthase 1)ADRA2C (α2C)NET (Norepinephrine Transporter)MOR (Mu opioid receptor)
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