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dexmedetomidine niosomes
- Development stage
- Unknown
- Lead developer
- Assiut University
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Rectal
01
Overview
Dexmedetomidine niosomes is a nanoparticle-based formulation of dexmedetomidine, a selective alpha-2 adrenergic agonist, developed by Assiut University. This formulation utilizes niosomes—vesicles composed of non-ionic surfactants—to enhance the rectal delivery and bioavailability of the drug. It is primarily being investigated for the management of postoperative pain in pediatric cancer patients, particularly those undergoing bone marrow procedures. By using nanotechnology, the formulation aims to optimize the pharmacokinetic and pharmacodynamic profile of dexmedetomidine, providing effective analgesia while potentially minimizing systemic variability associated with conventional rectal administration.
- Other names
- rectal dexmedetomidine niosomesniosomal dexmedetomidine
02
Targets
NaV (Voltage-gated sodium channels)NeuraminidaseADRA2A (α2A)
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