Drug intelligence / Profile preview

dexmethylphenidate

Development stage
Approved
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

Dexmethylphenidate is a central nervous system stimulant used primarily for the treatment of attention deficit hyperactivity disorder (ADHD). It is the d-enantiomer of methylphenidate and is considered more pharmacologically active than the racemic mixture. Dexmethylphenidate acts as a norepinephrine-dopamine reuptake inhibitor, blocking dopamine and norepinephrine transporters in synapses—especially in brain regions such as the thalamus and striatum. This leads to increased concentrations of these neurotransmitters in the synaptic cleft, which helps improve attention and decrease restlessness in patients with ADHD[1][3][5][8]. The drug is typically used alongside psychological, educational, or behavioral interventions. Developers: Novartis Manufacturers: Novartis

Brand names
FocalinFocalin XR
Other names
d-threo-methylphenidated-methylphenidate
02

Targets

DAT (Dopamine plasma membrane transport protein)SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)

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