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Dexmethylphenidate is a central nervous system stimulant used primarily for the treatment of attention deficit hyperactivity disorder (ADHD). It is the d-enantiomer of methylphenidate and is considered more pharmacologically active than the racemic mixture. Dexmethylphenidate acts as a norepinephrine-dopamine reuptake inhibitor, blocking dopamine and norepinephrine transporters in synapses—especially in brain regions such as the thalamus and striatum. This leads to increased concentrations of these neurotransmitters in the synaptic cleft, which helps improve attention and decrease restlessness in patients with ADHD[1][3][5][8]. The drug is typically used alongside psychological, educational, or behavioral interventions. Developers: Novartis Manufacturers: Novartis
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