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Dexosome
- Development stage
- Phase 2
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
**Dexosome** is a cell-free therapeutic vaccine derived from dendritic cells (DCs) loaded with tumor-associated antigens (TAAs) for cancer immunotherapy. It leverages exosomes secreted by DCs to present antigens, activating both adaptive (T lymphocytes) and innate (natural killer cells) immune responses against tumors. Dexosomes have demonstrated antitumor activity in preclinical mouse models and safety in human clinical trials, including phase I studies in advanced non-small cell lung carcinoma (NSCLC) and phase II in malignant melanoma, without significant adverse effects.[2][5]
- Other names
- dexosomes
02
Targets
CD80/CD86 costimulatory receptors axisIntercellular adhesion molecule 1/integrin adhesion axisγδ TCR (T-cell receptor)NCR3 (Natural cytotoxicity trigger receptor 3 (NKp30))NKG2D (Natural killer group 2 member D receptor)
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