dexpanthenol

Dexpanthenol, also known as D-panthenol or provitamin B5, is an alcohol analogue of pantothenic acid (vitamin B5). Upon administration, dexpanthenol is enzymatically cleaved and oxidized to pantothenic acid, which serves as an essential precursor for the synthesis of coenzyme A (CoA). Coenzyme A acts as a critical cofactor in numerous enzymatic reactions, including fatty acid synthesis, protein metabolism, and the tricarboxylic acid cycle. In dermatological applications, dexpanthenol acts as a humectant and emollient, improving skin hydration, reducing transepidermal water loss, and promoting fibroblast proliferation and re-epithelialization during wound healing. It is widely utilized in topical formulations for conditions such as atopic dermatitis, radiation dermatitis, and skin recovery following dermatological procedures. Additionally, dexpanthenol is used in ophthalmic gels for corneal re-epithelialization and dry eye syndrome, and has been investigated for its potential neuroprotective and cholinergic effects.

Brand names

BepanthenBepantolCorneregelSinecort

Other names

panthenolD-panthenol(+)-panthenolprovitamin B5