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Dextiva CPM
- Development stage
- Unknown
- Lead developer
- Wonne International
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Dextiva CPM is an oral syrup combination product marketed by Wonne International, containing the antitussive dextromethorphan hydrobromide and the first-generation antihistamine chlorpheniramine maleate. Dextromethorphan suppresses the cough reflex by acting as an agonist at sigma-1 receptors in the medullary cough center of the central nervous system. Chlorpheniramine maleate acts as a competitive antagonist at H1 histamine receptors, thereby reducing allergic symptoms such as sneezing, rhinorrhea, and itchy/watery eyes. This combination is indicated for the symptomatic relief of cough and upper respiratory symptoms associated with the common cold, hay fever, or other respiratory allergies.
- Brand names
- Dextiva CPMDEXTIVA CPM Syrup
- Other names
- dextromethorphan + chlorpheniraminedextromethorphan / chlorpheniramine
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)SERT (Sodium-dependent serotonin transporter)SIGMAR1 (Sigma non-opioid intracellular receptor 1)HRH1 (Histamine H1 Receptor)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)KCNH2 (Voltage-gated potassium channel subfamily H member 2)
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