dextran 40

Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran, a complex, branched polysaccharide with an average molecular weight of 40,000 daltons. Administered intravenously, it functions primarily as a plasma volume expander by increasing intravascular volume through its colloidal osmotic effect. Beyond volume expansion, Dextran 40 also improves microcirculation by reducing blood viscosity and inhibiting the aggregation and adhesiveness of erythrocytes and platelets. It is indicated for the adjunctive treatment of shock due to various causes such as hemorrhage, burns, surgery, or other trauma. Additionally, it is used as a priming fluid in pump oxygenators during extracorporeal circulation and for the prophylaxis of venous thrombosis and pulmonary embolism, particularly following high-risk surgical procedures like hip surgery.

Brand names

LMD in DextroseLMD in Sodium Chloride

Other names

Dextran-Mlow molecular weight dextran