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dextran conjugates
- Development stage
- Preclinical
- Lead developer
- NanoGroup
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Dextran conjugates represent a targeted drug delivery platform currently in preclinical development by NanoGroup for the treatment of various cancers. This technology utilizes dextran, a biocompatible and biodegradable polysaccharide, as a scaffold to create nanoparticle-based delivery systems. By conjugating therapeutic agents to the dextran backbone, the platform aims to enhance the pharmacokinetic properties, stability, and therapeutic index of anti-cancer drugs. The system is designed to facilitate targeted delivery to tumor sites, potentially reducing systemic toxicity, although the specific molecular targets and therapeutic payloads for the lead candidates are currently under determination.
- Other names
- dextran-based nanoparticle conjugates
02
Targets
DNATOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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