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dextrin 2-sulfate
- Development stage
- Phase 1
- Modality
- Small Molecules, Hydrogel Systems → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical, Vaginal, Rectal
01
Overview
Dextrin 2-sulfate (D2S) is a synthetic sulfated polysaccharide investigated primarily for its antiviral properties, especially as an inhibitor of HIV-1 infection. It acts by binding to cell surface proteins on activated human peripheral blood mononuclear cells and cultured T-cells, thereby blocking the entry and infection of HIV-1. Dextrin 2-sulfate demonstrated high anti-HIV-1 activity with low anticoagulant effects in preclinical studies. Its mechanism involves specific and saturable binding to target cell surfaces that are susceptible to HIV-1 infection[6][1]. The compound was explored as a potential microbicide for HIV prevention[1].
- Brand names
- EmmelleViraldon
- Other names
- D2SD-2SD 2Sdextrin sulphatedextrin 2-sulphatedextrin2-sulphatedextrin-2-sulphate
02
Targets
CD4 (T lymphocyte surface antigen)Tat (HIV-1 Tat)
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