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dextrin-2 sulphate
- Development stage
- Unknown
- Lead developer
- Innovata
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Vaginal
01
Overview
Dextrin-2 sulphate (Emmelle) is a sulphated polysaccharide polymer developed as a topical vaginal microbicide for the prevention of HIV transmission. It is a sulphated glucose polymer that acts as a polyanion, binding to the V3 loop of the HIV-1 gp120 envelope glycoprotein to block viral entry into host cells. Additionally, it has been proposed to induce the production of chemokines such as MIP-1α and MIP-1β, which block viral entry via the CCR5 co-receptor. Developed by ML Laboratories in collaboration with the Medical Research Council (MRC), it has been evaluated in Phase I and Phase II clinical trials for safety and efficacy in preventing HIV infection in sexually active women. It was selected over dextrin-6 sulphate due to its reduced anticoagulant activity while maintaining comparable anti-HIV efficacy.
- Brand names
- Emmelle
- Other names
- dextrin sulphatedextrin 2-sulphatedextrin2-sulphatedextrin-2-sulphate
02
Targets
CCR5 (C-C chemokine receptor type 5)Env (HIV-1 envelope glycoprotein)CXCR4 (C-X-C motif chemokine receptor 4)
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