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dextromethorphan + diphenhydramine + levomenthol
- Development stage
- Unknown
- Lead developer
- Navana Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pires D is a fixed-dose combination over-the-counter (OTC) cough and cold preparation developed and marketed by Navana Pharmaceuticals. It contains dextromethorphan (a centrally-acting cough suppressant), diphenhydramine (a first-generation antihistamine with antitussive and anticholinergic properties), and levomenthol (a cooling agent that soothes throat irritation). Together, these components work synergistically to provide relief from persistent, dry, irritating coughs and associated upper respiratory symptoms, while also aiding restful sleep.
- Brand names
- Pires DPires-D
- Other names
- dextromethorphan + diphenhydramine + levomentholdextromethorphan + levomenthol + diphenhydraminediphenhydramine + dextromethorphan + levomenthol
02
Targets
HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)SIGMAR1 (Sigma non-opioid intracellular receptor 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)NMDAR (Glutamate receptor ionotropic, NMDA)
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