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dextrose 15% + lidocaine 1%
- Development stage
- Phase 3
- Lead developer
- National and Kapodistrian University of Athens
- Modality
- Small Molecules
- Administration
- Infiltration
01
Overview
Dextrose 15% + lidocaine 1% is a combination therapy used in prolotherapy for the treatment of chronic musculoskeletal conditions. Developed for this specific application by the National and Kapodistrian University of Athens, the solution is injected into standardized acupuncture points (acupoints) to treat chronic non-specific low back pain. The hypertonic dextrose (15%) acts as a proliferant, inducing a localized inflammatory response that promotes tissue healing and collagen synthesis, while the lidocaine (1%) provides immediate, short-term analgesia by inhibiting voltage-gated sodium channels. This integrative approach combines regenerative medicine with neuroanatomical targeting to address refractory back pain.
- Other names
- Dextrose 15% and lidocaine 1% infiltrationDextrose-enhanced prolotherapyCombinational prolotherapy
02
Targets
SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)
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