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Prolotherapy-Hacettepe University-lateral epicondylitis refers to a specific therapeutic intervention evaluated in the clinical trial NCT04395417 by Hacettepe University. This treatment involves the peritendinous injection of a 15% hypertonic dextrose solution (composed of 30% dextrose, 2% lidocaine, and 0.9% saline) into the common extensor tendon origin at the lateral epicondyle. The primary indication is chronic lateral epicondylitis (tennis elbow). The mechanism of action involves inducing local tissue irritation and osmotic stress, which triggers a regenerative healing cascade, including cell proliferation and collagen synthesis, to strengthen and repair the degenerate tendon.
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