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DFP-10825
- Development stage
- Unknown
- Lead developer
- Delta-Fly Pharma
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, Nanoparticles → Drug Delivery Systems, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intraperitoneal
01
Overview
DFP-10825 is a liposomal RNAi therapeutic developed by Delta-Fly Pharma for the treatment of peritoneal disseminated cancers, including gastric, ovarian, and pancreatic cancers. It consists of a short hairpin RNA (shRNA) molecule encapsulated in a liposome, designed to target and knock down the expression of thymidylate synthase (TS). By inhibiting TS, an enzyme essential for DNA synthesis and repair, DFP-10825 aims to suppress tumor growth and overcome resistance to conventional fluoropyrimidine-based therapies. The drug is administered via intraperitoneal injection to directly target metastatic lesions within the abdominal cavity and is often evaluated in combination with taxanes.
02
Targets
TS (Thymidylate synthase)
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