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**Dfriz** is an oral fixed-dose combination tablet marketed by Sinsan Pharmaceuticals for **osteoarthritis**. It contains diacerein 50 mg, glucosamine 750 mg, and methylsulfonylmethane 250 mg. Diacerein is a symptomatic slow-acting osteoarthritis drug whose active metabolite rhein is associated with suppression of interleukin-1-mediated inflammatory and cartilage-degrading processes; glucosamine supports proteoglycan and cartilage-matrix synthesis; and methylsulfonylmethane is included for supportive anti-inflammatory and joint-symptom management. ([1mg.com](https://www.1mg.com/drugs/dfriz-750mg-50mg-250mg-tablet-427325))
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