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DHA

Development stage: Preclinical
Modality: Small Molecules
Administration: Oral, Intraperitoneal

Overview

DHA is an abbreviation that refers to two distinct compounds in the provided context: Docosahexaenoic acid and Dihydroartemisinin. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid vital for neurological growth and cognitive function. It acts as a precursor to specialized pro-resolving mediators like Maresin1, modulates microglial autophagy, and influences lipid metabolism. Dihydroartemisinin (DHA) is a derivative of artemisinin, known for its antimalarial and anticancer activities. It exerts its effects by inducing ferroptosis, modulating immune cell activity (Tfh, B, and Treg cells), and targeting various proteins involved in cancer progression such as AR, CASP3, CDK1, CDK4, PTK2, and MMP9.

Other names: Docosahexaenoic acidDihydroartemisinin

Targets

RXRA (Retinoid X receptor alpha)SLC27A1 (Long-chain fatty acid transport protein 1)FABP5 (Fatty acid-binding protein 5)

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