diacetoxyscirpenol

Diacetoxyscirpenol is a **type A trichothecene mycotoxin**, primarily produced by *Fusarium* fungi, and is part of a group of potent cytotoxins structurally characterized by a tricyclic sesquiterpenoid epoxide[1][5][6]. Trichothecene mycotoxins, including diacetoxyscirpenol, act as **potent inhibitors of protein synthesis**: they cross the plasma membrane and bind to ribosomes, disrupting the active site of peptidyl transferase in the large 28S ribosomal RNA[1][6]. This blocks the initiation, elongation, and termination phases of protein synthesis, leading to cell cycle disruption, apoptosis, ribotoxic stress responses, inhibition of DNA and RNA synthesis, and heightened oxidative stress[1][6]. As a result, diacetoxyscirpenol is cytotoxic to most eukaryotic cells, particularly those that are rapidly dividing, and has been studied as both an immunosuppressant and a potential anticancer agent (especially in clinical trials for leukemia and colorectal tumors, mostly discontinued before the late 1980s)[6]. It is known for its **extreme toxicity** by ingestion, inhalation, or parenteral administration, with noted effects including muscle weakness, nausea, vomiting, fever, and teratogenicity[2][6].

Other names

anguidineDASanguidin4,15-diacetoxyscirpenoldiacetoxysciroenoldiacetoxyscirpenol solution12,13-epoxytrichothec-9-ene-3,4,15-triol-4,15-diacetate3,5-diacetoxyscirpenoltrichothec-9-ene-3alpha,4beta,15-triol, 12,13-epoxy-4,15-diacetatescirpenetriol 4,15-diacetate