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Drug intelligence / Profile preview
Diakine-DK12-IFNa (EGFR) Intratumoral
- Development stage
- Preclinical
- Lead developer
- DEKA Biosciences
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Cytokines & Interferons → Recombinant Proteins and Enzymes
- Administration
- Intratumoral
01
Overview
**Diakine-DK12-IFNa (EGFR) Intratumoral** is a preclinical, intratumorally administered EGFR-targeted immunocytokine developed by Deka Biosciences for EGFR-expressing solid tumors. It is a single recombinant cytokine fusion protein designed to localize within EGFR-positive tumor tissue while delivering interleukin-12 and interferon-alpha signaling locally, with the aim of stimulating innate and adaptive antitumor immune responses while limiting systemic cytokine exposure.
02
Targets
EGFR (Epidermal growth factor receptor)IFNAR (Immune system modulation via type I interferon receptor)IFNAR1 (Interferon alpha/beta receptor 1)IFNAR2 (Interferon alpha/beta receptor subunit 2)IL12RB2 (Interleukin-12 receptor subunit beta-2)
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