diane-35 + metformin + clomiphene citrate + human menopausal gonadotropin

This is a multi-drug combination therapy consisting of four active pharmaceutical ingredients commonly used in the management of female infertility, polycystic ovary syndrome (PCOS), and related reproductive or endocrine disorders. The components are: **Diane-35** (cyproterone acetate and ethinylestradiol): A combined oral contraceptive with anti-androgenic properties, used primarily for androgenization symptoms such as severe acne or hirsutism in women. It contains cyproterone acetate (a progestogen with anti-androgen effects) and ethinylestradiol (an estrogen)[1][2][3][8]. **Metformin:** An oral biguanide antidiabetic agent that improves insulin sensitivity, often prescribed off-label for PCOS to address insulin resistance. **Clomiphene Citrate:** A selective estrogen receptor modulator that induces ovulation by stimulating the release of pituitary gonadotropins[7][10]. **Human Menopausal Gonadotropin (hMG):** A purified preparation containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH), used to stimulate ovarian follicular development in women undergoing fertility treatment. This regimen targets multiple aspects of reproductive endocrinology: hormonal regulation, ovulation induction, metabolic correction, and direct ovarian stimulation. It is typically employed under specialist supervision for complex cases such as anovulatory infertility associated with PCOS.

Other names

cyproterone acetate/ethinylestradiol + metformin + clomiphene citrate + hMG