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diapep277
- Development stage
- Discontinued
- Lead developer
- Amgen
- Modality
- Peptides, Small Molecules
- Administration
- Subcutaneous
01
Overview
DiaPep277 is a synthetic 24-amino acid peptide derived from the human heat shock protein 60 (Hsp60, residues 437–460). It was developed as an immunomodulatory therapy for type 1 diabetes mellitus and other autoimmune diseases. The drug acts by modulating the immune response, specifically promoting anti-inflammatory effects and shifting cytokine secretion away from a pro-inflammatory profile through interaction with Toll-like receptor 2 (TLR2). This mechanism aims to preserve pancreatic beta-cell function by reducing autoimmune destruction. Clinical trials demonstrated that DiaPep277 is safe and may help maintain endogenous insulin production in some patients with recent-onset type 1 diabetes, though efficacy results were modest. Development was halted after issues related to phase III trial data integrity[1][3][5][6][8].
- Other names
- F8778UWB0AF-8778UWB0AF 8778UWB0A179822-83-4
02
Targets
TLR2 (Toll-like Receptor 2)
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