dibenzyl trisulfide

Dibenzyl trisulfide (DTS) is a naturally occurring organosulfur compound and secondary metabolite isolated from the plant *Petiveria alliacea* (commonly known as guinea hen weed or Anamú). It has been investigated for its immunomodulatory, antimalarial, and anticancer properties. In oncology, DTS acts as a small-molecule kinase inhibitor, selectively targeting ribosomal protein S6 kinase alpha-1 (RSK1) and modulating the mitogen-activated protein kinase (MAPK) signaling pathway (specifically ERK1/ERK2). It also induces lysosomal membrane permeabilization, leading to cathepsin B release and caspase-independent cell death in triple-negative breast cancer (TNBC) and other cancer types. Additionally, DTS has been shown to alter erythrocyte biophysical properties, increasing deformability and reducing *Plasmodium falciparum* invasion and adhesion, suggesting potential utility in malaria.

Other names

DTSdibenzyl trisulphide