dibotermin alfa + biphasic calcium phosphate

**Dibotermin alfa + biphasic calcium phosphate** is a combination product intended for use in bone regeneration and repair applications, particularly in orthopedic and dental procedures. **Dibotermin alfa** is a recombinant form of human bone morphogenetic protein-2 (rhBMP-2), a member of the TGF-β superfamily, known for its potent osteoinductive properties—stimulating differentiation of mesenchymal progenitor cells into osteoblasts and chondrocytes, thus promoting new bone and cartilage formation[1][2][3]. **Biphasic calcium phosphate (BCP)** is a synthetic bone graft material made of a mixture of hydroxyapatite and beta-tricalcium phosphate, designed to provide both osteoconductive support and gradual resorption, allowing for integration with native bone tissue. When dibotermin alfa is combined with BCP, the protein actively induces bone formation, while the BCP acts as a scaffold for bone ingrowth and eventual replacement by native bone. This combination is utilized in applications such as long bone fractures, bone defect repair, and dental bone augmentation[1][2][4].