Drug intelligence / Profile preview

dibromothymoquinone

Development stage
Unknown
Modality
Small Molecules
01

Overview

Dibromothymoquinone is a synthetic halogenated derivative of thymoquinone and belongs to the class of p-benzoquinones. It is primarily used as a research tool in photosynthesis studies due to its ability to inhibit the cytochrome b₆f complex in chloroplasts. At low concentrations it acts as a plastoquinone antagonist by inhibiting reduction of hydrophilic electron acceptors; at higher concentrations it can act as an electron acceptor itself. Its main mechanism involves blocking plastoquinol oxidation and disrupting electron flow between photosystem II and I in photosynthetic organisms. Dibromothymoquinone has also been shown to bind specific proteins such as KaiA involved in circadian rhythms[1][2][5].

Other names
2,5-dibromo-3-isopropyl-6-methylbenzoquinone2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone2,5-dibromo-6-isopropyl-3-methyl-1,4-benzoquinone2,5-cyclohexadiene-1,4-dione, 2,5-dibromo-3-methyl-6-(1-methylethyl)-
02

Targets

bc1 complex (Cytochrome bc1 complex (plasmodium))

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