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Dibrompropamidine is an aromatic diamidine compound classified as an antiseptic and disinfectant. It is primarily used in the form of its salt, dibrompropamidine isethionate, in topical preparations such as eyedrops and ointments for the treatment of minor eye and eyelid infections in adults and children. The drug exhibits broad-spectrum antibacterial activity, including efficacy against antibiotic-resistant staphylococci and some Gram-negative bacilli. Its mechanism of action involves disruption of microbial cell membranes—leading to leakage of cellular contents—and inhibition of nucleic acid synthesis, which prevents bacterial growth. Dibrompropamidine retains activity even in the presence of organic matter like pus or lacrimal secretions[1][5][6][8].
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