dichloroquine

Dichloroquine is a non-specific term used in pharmaceutical and toxicological literature to refer to several distinct chlorinated quinoline derivatives. Most commonly, in historical medical contexts such as the study of Subacute Myelo-Optico-Neuropathy (S.M.O.N.), it refers to **5,7-dichloro-8-quinolinol** (INN: **chlorquinaldol**), a halogenated hydroxyquinoline with antibacterial and antifungal properties used primarily for skin infections. In the field of antimalarial research, the term is often used as a shorthand for **4,7-dichloroquinoline**, a critical chemical intermediate in the synthesis of 4-aminoquinoline drugs like chloroquine. Additionally, the name has been applied to novel experimental derivatives, such as the heme-binding compound **CQ-D2**, which are investigated for their ability to prevent oxidative damage in hemoglobinopathies like beta-thalassemia or to enhance curative outcomes in cerebral malaria.

Other names

5,7-dichloro-8-quinolinolchlorquinaldol4,7-dichloroquinoline5,7-dichloro-8-hydroxyquinoline4,7-dichloroquine