Drug intelligence / Profile preview

dichrostachys glomerata extract

Development stage
Phase 2
Lead developer
Gateway Health Alliances
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Dichrostachys glomerata extract is a standardized nutraceutical derived from the fruit pods and other parts of the Dichrostachys glomerata plant (commonly known as "sickle bush" or "African pepper"), traditionally used in West and Central African herbal medicine[7][9][10]. Modern clinical studies have demonstrated that supplementation with this extract can support metabolic health by modulating key hormones such as GLP-1, insulin, leptin, and adiponectin; it also reduces oxidative stress[1][8]. The primary indications supported by clinical evidence include weight management in overweight or mildly obese adults (with reductions in body weight and improvements in metabolic syndrome markers), improvement of sleep quality (including insomnia symptoms), enhancement of mood and cognitive wellness, reduction of food cravings, improved daytime activity levels, cardiovascular risk factor reduction (such as blood pressure and cholesterol), antioxidant effects, glycemic control (lowering fasting serum glucose), and overall quality of life improvements[1][2][3][4][5][6][7][8]. The mechanism is believed to involve hormonal modulation related to appetite regulation/metabolism as well as antioxidant/anti-inflammatory pathways. It is not a pharmaceutical drug but rather a dietary supplement ingredient.

Brand names
SomnorilDyglomera
Other names
Dichrostachys glomerata extractD. glomerata extractsickle bush extractAfrican pepper extract
02

Targets

AdipoR (Adiponectin receptor)LEPR (Leptin receptor)GLP1R (GLP-1R)

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