diclofenac + methyl salicylate + menthol

Diclofenac Gel (specifically the formulation developed by Hanbet Pharmaceuticals) is a topical combination drug containing the nonsteroidal anti-inflammatory drug (NSAID) diclofenac, along with methyl salicylate and menthol. The primary mechanism of action involves the inhibition of cyclooxygenase enzymes (COX-1 and COX-2), which prevents the synthesis of prostaglandins responsible for pain and inflammation. Methyl salicylate serves as a counter-irritant and rubefacient, while menthol provides a cooling sensation and local analgesic effect by acting on TRPM8 receptors. This specific formulation is approved by NAFDAC in Nigeria (Registration No. A4-9805) under the brand name Dicloseed Gel for the relief of pain and inflammation associated with musculoskeletal and joint conditions such as osteoarthritis, rheumatoid arthritis, and minor injuries.

Brand names

Dicloseed Gel

Other names

Diclofenac Gel