Drug intelligence / Profile preview

diclofenac + serratiopeptidase (Med Manor Organics)

Development stage
Unknown
Lead developer
Med Manor Organics
Modality
Small Molecules, Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

Spade-D is a combination oral tablet containing diclofenac potassium (50 mg), a non-steroidal anti-inflammatory drug (NSAID), and serratiopeptidase (10 mg), a proteolytic enzyme. Developed by Med Manor Organics, it is used to manage pain, inflammation, and swelling associated with musculoskeletal disorders, joint conditions (such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis), and post-operative recovery. Diclofenac works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of inflammatory prostaglandins. Serratiopeptidase acts synergistically by breaking down abnormal proteins, fibrin, and inflammatory debris at the site of injury, which reduces localized edema, improves microcirculation, and facilitates tissue repair.

Brand names
Spade DSpade-D
Other names
diclofenac + serrapeptasediclofenac + serratiopeptidasediclofenac potassium + serrapeptasediclofenac potassium + serratiopeptidase
02

Targets

BK (Bradykinin)Fibrin (Factor Ia)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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