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Drug intelligence / Profile preview
diclofenac hydroxyethylpyrrolidine
- Development stage
- Unknown
- Lead developer
- Specialized Arab Hospital
- Modality
- Small Molecules
- Administration
- Intramuscular
01
Overview
Diclofenac hydroxyethylpyrrolidine is a salt of the non-steroidal anti-inflammatory drug (NSAID) diclofenac. It functions as a potent inhibitor of the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are responsible for the production of prostaglandins that mediate pain, fever, and inflammation. In the clinical trial conducted by the Specialized Arab Hospital, this specific formulation was administered via intramuscular injection to evaluate its efficacy in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. By inhibiting the early inflammatory response triggered during the ERCP procedure, the drug aims to reduce the incidence and severity of acute pancreatitis in high-risk patients.
- Brand names
- AkisFlector
- Other names
- diclofenac epolamineDHEP
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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