Drug intelligence / Profile preview

diclofenac potassium + paracetamol

Development stage
Unknown
Lead developer
Aarise Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

Diclofox-P is a fixed-dose combination analgesic and antipyretic medication developed by Aarise Pharmaceuticals. It contains diclofenac potassium, a non-steroidal anti-inflammatory drug (NSAID), and paracetamol (acetaminophen). Diclofenac potassium provides rapid-onset relief by inhibiting the cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the synthesis of prostaglandins that mediate pain and inflammation. Paracetamol acts primarily within the central nervous system to elevate the pain threshold and reduce fever, potentially through the inhibition of a central COX variant (often referred to as COX-3). This combination is typically indicated for the management of acute pain and inflammation associated with musculoskeletal disorders, post-operative recovery, and various arthritic conditions such as rheumatoid arthritis and osteoarthritis.

Brand names
Diclofox-P
Other names
diclofenac potassium and paracetamol tablets
02

Targets

CYP2E115-LOX (Lysyl Oxidase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TYMP (Thymidine phosphorylase)PPARG (Peroxisome proliferator-activated receptor gamma)NaV (Voltage-gated sodium channels)PGHS-1 (Prostaglandin G/H Synthase 1)CNR1 (Cannabinoid receptor 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ASIC (ASIC family)FAAHTRPA1 (Transient receptor potential cation channel subfamily A member 1)NMDAR (Glutamate receptor ionotropic, NMDA)KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)TACR1 (Neurokinin‑1 Receptor)

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