Drug intelligence / Profile preview

diclofenac sodium

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Intramuscular, Intravenous, Ophthalmic, Oral, Rectal, Topical
01

Overview

Diklofenak Sodyum (diclofenac sodium) is a well-established, non-steroidal anti-inflammatory drug (NSAID) and small molecule compound. It works by non-selectively inhibiting the cyclooxygenase enzymes, Prostaglandin G/H synthase 1 (COX-1) and Prostaglandin G/H synthase 2 (COX-2), thereby reducing the synthesis of prostaglandins, which are key biological mediators of pain, fever, and inflammation. Originally developed by Ciba-Geigy (now Novartis), diclofenac sodium is widely approved and marketed globally under various brand names, including Voltaren, for the management of acute and chronic pain, inflammatory conditions, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and postoperative pain.

Brand names
DicloronDiclomecDylojectEfmodPennsaidSolarazeVoltarenVoltaren Arthritis PainVoltaren EmulgelVoltaren OphthaVoltaren RetardVoltaren XR
Other names
Diklofenak Sodyumdiclofenacdiclofenac sodiumdiclofenac sodium saltsodium diclofenac
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)

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