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Drug intelligence / Profile preview
diclofenac sodium
- Development stage
- Approved
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous, Ophthalmic, Oral, Rectal, Topical
01
Overview
Diklofenak Sodyum (diclofenac sodium) is a well-established, non-steroidal anti-inflammatory drug (NSAID) and small molecule compound. It works by non-selectively inhibiting the cyclooxygenase enzymes, Prostaglandin G/H synthase 1 (COX-1) and Prostaglandin G/H synthase 2 (COX-2), thereby reducing the synthesis of prostaglandins, which are key biological mediators of pain, fever, and inflammation. Originally developed by Ciba-Geigy (now Novartis), diclofenac sodium is widely approved and marketed globally under various brand names, including Voltaren, for the management of acute and chronic pain, inflammatory conditions, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and postoperative pain.
- Brand names
- DicloronDiclomecDylojectEfmodPennsaidSolarazeVoltarenVoltaren Arthritis PainVoltaren EmulgelVoltaren OphthaVoltaren RetardVoltaren XR
- Other names
- Diklofenak Sodyumdiclofenacdiclofenac sodiumdiclofenac sodium saltsodium diclofenac
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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