didemnin B

Didemnin B is a cyclic depsipeptide originally extracted from the Caribbean tunicate Trididemnum cyanophorum. It belongs to the class of marine-derived compounds known as didemnins, which are characterized by their unique cyclic peptide structures. Didemnin B exhibits potent antitumor, antiviral, and immunosuppressive activities. Its primary mechanism of action involves inhibition of protein synthesis by preventing eukaryotic elongation factor 2 (eEF2)-dependent translocation during translation, leading to rapid and irreversible suppression of cell growth. Additionally, it activates caspases to induce apoptosis in target cells. Didemnin B has demonstrated significant cytotoxicity against various cancer cell lines and has shown activity in preclinical models for leukemia and melanoma. The compound also possesses notable antiviral properties against several viruses and exerts immunosuppressive effects[1][2][3][4][6].

Other names

didemnin B