dieckol

Dieckol is a **phlorotannin**, a type of marine polyphenol compound isolated mainly from brown algae including *Ecklonia cava*, *Ecklonia stolonifera*, and *Eisenia bicyclis*. It exhibits a range of bioactivities, including **antioxidant**, **anticoagulant**, **hepatoprotective**, **antimicrobial**, **anticancer**, **antiaging**, **antidiabetic**, **neuroprotective**, and anti-inflammatory properties[1][5][8][9]. Mechanistically, dieckol acts as a **positive allosteric modulator** at the benzodiazepine (BZD) binding site of **GABA-A receptor**, enhancing non-REM sleep in preclinical models[3]. It is also reported to inhibit **alpha-glucosidase**, **PI3K/AKT signaling** (relevant in cancer cell proliferation), and **platelet aggregation/thrombosis**[1][3][9]. Dieckol is under investigation for a variety of potential uses including in the food, pharmaceutical, and cosmetic industries, but is not an approved pharmaceutical drug[5].

Other names

Dieckol8,4'''-Dieckol4-[4-[6-(3,5-dihydroxyphenoxy)-4,7,9-trihydroxydibenzo-p-dioxin-2-yl]oxy-3,5-dihydroxyphenoxy]dibenzo-p-dioxin-1,3,6,8-tetrol4-(4-((6-(3,5-Dihydroxyphenoxy)-4,7,9-trihydroxydibenzo[b,e][1,4]dioxin-2-yl)oxy)-3,5-dihydroxyphenoxy)dibenzo[b,e][1,4]dioxin-1,3,6,8-tetrol