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diethylamine tetrathiomolybdate
- Development stage
- Preclinical
- Lead developer
- University College London
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Diethylamine tetrathiomolybdate (DE-ATTM or DEATTM) is an investigational small molecule sulfide donor developed by University College London (UCL) and King's College London (KCL) for the treatment of ischemia-reperfusion (I/R) injury and severe hemorrhage. The drug acts as a controlled-release intracellular sulfide donor that partially and reversibly inhibits mitochondrial complex IV (cytochrome c oxidase). This temporary inhibition limits the generation of damaging reactive oxygen species (ROS) upon tissue reoxygenation and resuscitation. Preclinical studies in rat and pig models of myocardial, cerebral, and hemorrhage-reperfusion injury have demonstrated significant protective efficacy, reducing infarct size and improving survival.
- Other names
- crystalline diethylamine tetrathiomolybdate
02
Targets
COX7C (Cytochrome c oxidase subunit 7C, mitochondrial)Misfolded SOD1
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